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CAS 5680-79-5
methyl glycinate hydrochloride
登记编号：ROXA-021、VADA-006、EPTI-017
应用背景（按来源药适应症）
贫血罗沙司他慢性肾功能不全伐度司他贫血伐度司他不稳定型心绞痛依替巴肽心肌梗塞依替巴肽缺血性卒中依替巴肽急性冠脉综合征依替巴肽镰状细胞血症依替巴肽ST段抬高型心肌梗死依替巴肽
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-phenoxyphthalic acid→4-nitrophthalonitrile→4-phenoxyphthalonitrile→5-phenoxyisobenzofuran-1,3-dione→methyl 2-cyanoacetate→2-(4-(methoxycarbonyl)oxazol-5-yl)-4-phenoxybenzoic acid→methyl 4-hydroxy-1-oxo-7-phenoxy-1,2-dihydroisoquinoline-3-carboxylate→methyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate→methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate→4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid→methyl glycinate hydrochloride→methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate
3,5-dichloropicolinonitrile→(3-chlorophenyl)boronic acid→methyl glycinate hydrochloride→methyl (5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycinate→3,5-bis(benzyloxy)picolinonitrile→3,5-bis(benzyloxy)picolinic acid hydrochloride→methyl (3,5-bis(benzyloxy)picolinoyl)glycinate→methyl (3,5-dihydroxypicolinoyl)glycinate→methyl (3-hydroxy-5-(((trifluoromethyl)sulfonyl)oxy)picolinoyl)glycinate
2-aminoacetic acid→methyl glycinate hydrochloride→(S)-2-(((benzyloxy)carbonyl)amino)-6-guanidinohexanoic acid→(S)-methyl 2-(2-amino-6-guanidinohexanamido)acetate→3-((acetamidomethyl)thio)propanoic acid→(S)-10-(4-guanidinobutyl)-2,8,11-trioxo-5-thia-3,9,12-triazatetradecan-14-oic acid→(S)-methyl 1-((S)-2-((S)-2-amino-4-(tert-butoxy)-4-oxobutanamido)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→(S)-1-((10S,16S,19S)-19-((1H-indol-3-yl)methyl)-16-(2-(tert-butoxy)-2-oxoethyl)-10-(4-guanidinobutyl)-2,8,11,14,17-pentaoxo-5-thia-3,9,12,15,18-pentaazaicosan-20-oyl)pyrrolidine-2-carboxylic acid→(R)-3-((acetamidomethyl)thio)-2-aminopropanamide→(S)-pyrrolidine-2-carboxylic acid→methyl L-prolinate hydrochloride→(S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid→(S)-methyl 1-((S)-2-amino-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→(S)-2-(((benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid
(((9H-fluoren-9-yl)methoxy)carbonyl)-L-proline→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid→3-(tritylthio)propanoic acid→methyl glycinate hydrochloride→(S)-2-(((benzyloxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)hexanoic acid→(S)-methyl 2-(2-(((benzyloxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)hexanamido)acetate→(S)-methyl 2-(6-((tert-butoxycarbonyl)amino)-2-(3-(tritylthio)propanamido)hexanamido)acetate→(S)-tert-butyl 3-amino-4-(((S)-1-((S)-2-(((R)-1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-4-oxobutanoate→(10S,16S)-tert-butyl 16-(((S)-1-((S)-2-(((R)-1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-2,2-dimethyl-4,11,14-trioxo-10-(3-(tritylthio)propanamido)-3-oxa-5,12,15-triazaoctadecan-18-oate→2-((3R,11S,17S,20S,25aS)-20-((1H-indol-3-yl)methyl)-11-(4-aminobutyl)-3-carbamoyl-1,9,12,15,18,21-hexaoxodocosahydro-1H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl)acetic acid hydrochloride→amino(imino)methanesulfonic acid hydrate→(R)-2-amino-3-(tritylthio)propanamide→(S)-(9H-fluoren-9-yl)methyl 2-(((R)-1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamoyl)pyrrolidine-1-carboxylate→(((9H-fluoren-9-yl)methoxy)carbonyl)-L-tryptophan→(9H-fluoren-9-yl)methyl ((S)-1-((S)-2-(((R)-1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamate→(S)-tert-butyl 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(((S)-1-((S)-2-(((R)-1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-4-oxobutanoate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 4-hydroxy-1-methyl-7-phenoxy-3-Isoquinolinecarboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-hydroxy-1-methyl-7-phenoxy-3-Isoquinolinecarboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 5-Phenoxyisobenzofuran-1(3H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid ethyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。