CAS 62-53-3

Aminobenzeneaniline

登记编号：(V)819703-2-a、PERAM-031、SELT-005、Atorvastatin-049、IVAC-001、FENT-004、(I)91353-9-a、(I)91353-11-a、(XXVII)700647-1-c、NELF-013

应用背景（按来源药适应症）

胃肠道间质瘤瑞派替尼强直阵挛性癫痫吡仑帕奈癫痫部分性发作吡仑帕奈癫痫吡仑帕奈癫痫发作吡仑帕奈丛状神经纤维瘤硫酸氢司美替尼神经纤维瘤病I型硫酸氢司美替尼心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利囊性纤维化艾伐卡托慢性支气管炎艾伐卡托慢性阻塞性肺疾病艾伐卡托鼻窦炎艾伐卡托疼痛盐酸布比卡因/枸橼酸芬太尼背痛双氯芬酸钠/盐酸乙哌立松高脂血症阿托伐他汀锶蛛网膜下腔出血阿托伐他汀锶高血压阿托伐他汀锶疼痛芬太尼早产儿疾病芬太尼术后疼痛芬太尼癌症疼痛芬太尼实体瘤芬太尼手术疼痛芬太尼骨关节炎双氯芬酸钠类风湿关节炎双氯芬酸钠强直性脊柱炎双氯芬酸钠胆总管疾病双氯芬酸钠牙髓疾病双氯芬酸钠关节炎双氯芬酸钠蠕形螨性睑缘炎洛替拉纳螨虫感染洛替拉纳莱姆病洛替拉纳酒渣鼻洛替拉纳睑板腺功能障碍洛替拉纳HIV感染甲磺酸奈非那韦骨髓纤维化甲磺酸奈非那韦子宫颈功能不全甲磺酸奈非那韦系统性红斑狼疮甲磺酸奈非那韦非小细胞肺癌甲磺酸奈非那韦巨细胞病毒性视网膜炎甲磺酸奈非那韦

来源药（使用该中间体的合成路线）

品种	梯队	到期年
瑞派替尼Ripretinib	Tier C · 观察 / 贸易	2032
吡仑帕奈Perampanel Hydrate	Tier C · 观察 / 贸易	2028
硫酸氢司美替尼Selumetinib sulfate	Tier C · 观察 / 贸易	2032
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril	Tier C · 观察 / 贸易	-
艾伐卡托Ivacaftor	Tier B · 提前布局	-
盐酸布比卡因/枸橼酸芬太尼Bupivacaine Hydrochloride/Fentanyl Citrate	Tier C · 观察 / 贸易	-
双氯芬酸钠/盐酸乙哌立松Diclofenac Sodium/Eperisone Hydrochloride	Tier C · 观察 / 贸易	-
阿托伐他汀锶Atorvastatin strontium	Tier C · 观察 / 贸易	-
芬太尼Fentanyl	Tier C · 观察 / 贸易	-
双氯芬酸钠Diclofenac Sodium	Tier C · 观察 / 贸易	-
洛替拉纳Lotilaner	Tier C · 观察 / 贸易	-
甲磺酸奈非那韦Nelfinavir Mesylate	Tier C · 观察 / 贸易	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

瑞派替尼优化路线步数：5总收率：/

Methyl (2-bromo-4-fluoro-5-nitrophenyl)acetate→6-Chloro-4-nitropyridine-3-carbaldehyde→Methyl (2Z)-2-(2-bromo-4-fluoro-5-nitrophenyl)-3-(6-chloro-4-nitropyridin-3-yl)prop-2-enoate→3-(5-Amino-2-bromo-4-fluorophenyl)-7-chloro-1,6-naphthyridin-2(1H)-one→Aminobenzene→1,1,1-Trichloromethanol 1,1'-carbonate→N-[4-Bromo-5-(7-chloro-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→1-Iodoethane→N-[4-Bromo-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→Aminomethane

吡仑帕奈优化路线步数：3总收率：17.7 g

2-(2-cyanophenyl)acetic acid→aniline→2-(2-cyanophenyl)-N-phenylacetamide→PERAM-033→2-(pyridin-2-yl)acetic acid hydrochloride

硫酸氢司美替尼原研路线步数：11总收率：2.11 g

2,3,4-trifluorobenzoic acid→2,3,4-trifluoro-5-nitrobenzoic acid→4-amino-2,3-difluoro-5-nitrobenzoic acid→methyl 4-amino-2,3-difluoro-5-nitrobenzoate→aniline→SELT-006→SELT-007→SELT-008→SELT-009→SELT-010→SELT-011→methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate→SELT-013

阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利优化路线步数：7总收率：/

4-Methyl-3-oxopentanoic acid methyl ester→4-Methyl-3-oxopentanoic acid 4-methoxybenzyl ester→Benzaldehyde→2-Benzylidene-4-methyl-3-oxopentanoic acid 4-methoxybenzyl ester→1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid→(4-Fluorophenyl)methanone→2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid 4-methoxybenzyl ester→5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol→1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid 4-methoxybenzyl ester→Aminobenzene→1-[3(R)-[tert-butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide→1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-oxopentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide

艾伐卡托原研路线步数：8总收率：/

aniline→diethyl 2-(ethoxymethylene)malonate→diethyl 2-((phenylamino)methylene)malonate→ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate→4-oxo-1,4-dihydroquinoline-3-carboxylic acid→5-amino-2,4-di-tert-butylphenol→2,4-di-tert-butylphenol→2,4-di-tert-butylphenyl methyl carbonate→2,4-di-tert-butyl-5-nitrophenyl methyl carbonate→2,4-di-tert-butyl-5-nitrophenol

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质
Unibest Nantong cGMP Site	2-bromo-3-methyl-5-acetylthiophene Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	methyl 5-acetyl-3-methylthiophene-2-carboxylate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	5-acetyl-3-methyl-2-Thiophenecarboxylic acid Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。