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CAS 75-03-6
1-Iodoethane
登记编号：(VIII)819703-2-a、(II)638294-3-a、(VII)638294-14-a、(III)115092-6-a、(III)115092-8-a、Atosiban-054、Mosapride Citrate-002、(XII)989842-1-b
应用背景（按来源药适应症）
胃肠道间质瘤瑞派替尼收缩性心力衰竭非奈利酮舒张期心力衰竭非奈利酮心脏衰竭非奈利酮慢性肾功能不全非奈利酮糖尿病肾病非奈利酮二型糖尿病非奈利酮青光眼盐酸普索洛尔/盐酸毛果芸香碱闭角型青光眼盐酸毛果芸香碱高眼压盐酸毛果芸香碱开角型青光眼盐酸毛果芸香碱瞳孔缩小盐酸毛果芸香碱Sjtoegren综合征盐酸毛果芸香碱虹膜炎盐酸毛果芸香碱产科分娩（早产）阿托西班醋酸盐早产（孕37周前）阿托西班醋酸盐子宫内膜异位症阿托西班醋酸盐胃炎枸橼酸莫沙必利肠内喂养不耐受枸橼酸莫沙必利肠易激综合征枸橼酸莫沙必利消化不良枸橼酸莫沙必利便秘枸橼酸莫沙必利斑块银屑病莫米司特溃疡性结肠炎莫米司特白塞病综合征莫米司特银屑病莫米司特慢性阻塞性肺疾病莫米司特特应性皮炎莫米司特
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 瑞派替尼Ripretinib | Tier C · 观察 / 贸易 | 2032 |
| 非奈利酮Finerenone | Tier C · 观察 / 贸易 | 2030 |
| 盐酸普索洛尔/盐酸毛果芸香碱Proxodolol hydrochloride/Pilocarpine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 盐酸毛果芸香碱Pilocarpine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 阿托西班醋酸盐Atosiban acetate | Tier C · 观察 / 贸易 | - |
| 枸橼酸莫沙必利Mosapride Citrate | Tier C · 观察 / 贸易 | - |
| 莫米司特Mufemilast | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
Methyl (2-bromo-4-fluoro-5-nitrophenyl)acetate→6-Chloro-4-nitropyridine-3-carbaldehyde→Methyl (2Z)-2-(2-bromo-4-fluoro-5-nitrophenyl)-3-(6-chloro-4-nitropyridin-3-yl)prop-2-enoate→3-(5-Amino-2-bromo-4-fluorophenyl)-7-chloro-1,6-naphthyridin-2(1H)-one→Aminobenzene→1,1,1-Trichloromethanol 1,1'-carbonate→N-[4-Bromo-5-(7-chloro-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→1-Iodoethane→N-[4-Bromo-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→Aminomethane
4-Amino-5-methylpyridin-2(1H)-one→1-Iodoethane→2-Ethoxy-5-methylpyridin-4-amine→N-(2-Ethoxy-5-methylpyridin-4-yl)-2,2-dimethylpropanamide→2-Methoxy-4-cyanobenzaldehyde→N-[3-[(4-Cyano-2-methoxyphenyl)(hydroxy)methyl]-2-ethoxy-5-methylpyridin-4-yl]-2,2-dimethylpropanamide→4-[(4-Amino-2-ethoxy-5-methylpyridin-3-yl)(hydroxy)methyl]-3-methoxybenzonitrile→3-Oxobutanamide→(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxamide→(aS)-10,16-Di(anthracen-9-yl)-13-hydroxy-12,14-dioxa-13lambda5-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene 13-oxide
4-Bromo-2-methoxybenzaldehyde→3-Oxobutanamide→(2Z)-2-[(4-Bromo-2-methoxyphenyl)methylidene]-3-oxobutanamide→4-Amino-5-methylpyridin-2(1H)-one→4-(4-Bromo-2-methoxyphenyl)-2,5-dihydroxy-2,8-dimethyl-1,2,3,4-tetrahydro-1,6-naphthyridine-3-carboxamide→4-(4-Bromo-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→1-Iodoethane→4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→(4S)-4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
(2R)-2-Hydroxysuccinic acid→(R)-2-Hydroxysuccinic acid dimethylester→1-Iodoethane→Diethyl (2S,3R)-2-methyl-3-hydroxysuccinate→Dimethyl (2S,3R)-2-ethyl-3-[(4-nitrobenzene-1-sulfonyl)oxy]butanedioate→Dimethyl (3R)-2-bromo-3-ethylbutanedioate→1-Methyl-1H-imidazole-5-carbaldehyde→Methyl (3S,4S)-4-ethyl-2-(1-methyl-1H-imidazol-5-yl)-5-oxooxolane-3-carboxylate→(2S,3R)-2-Ethyl-4-methoxy-3-[(1-methyl-1H-imidazol-5-yl)methyl]-4-oxobutanoic acid
(2R)-2-Hydroxysuccinic acid→(R)-Diethyl malate→(R)-Diisopropyl 2-hydroxysuccinate→1-Iodoethane→Diethyl (2S,3R)-2-ethyl-3-hydroxybutanedioate→Dipropan-2-yl (2S,3R)-2-ethyl-3-hydroxybutanedioate→Diethyl (2S,3R)-2-ethyl-3-[(4-nitrobenzene-1-sulfonyl)oxy]butanedioate→Dipropan-2-yl (2S,3R)-2-ethyl-3-[(4-nitrobenzene-1-sulfonyl)oxy]butanedioate→Diethyl (3R)-2-bromo-3-ethylbutanedioate→Diisopropyl 2-bromo-3(R)-ethyl-butanedioate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。