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CAS 824-94-2
1-(chloromethyl)-4-methoxybenzene4-Methoxybenzyl chloride
登记编号：EFAV-010、Lopix-016
应用背景（按来源药适应症）
HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯HIV感染依非韦伦克-亚综合征依非韦伦阿尔茨海默病依非韦伦胰腺癌依非韦伦前列腺癌依非韦伦非霍奇金淋巴瘤依非韦伦瘙痒症氯马昔巴特进行性家族性肝内胆汁淤积症氯马昔巴特Alagille综合征氯马昔巴特胆汁淤积氯马昔巴特肝脏疾病氯马昔巴特肝内胆汁淤积氯马昔巴特
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C · 观察 / 贸易 | - |
| 依非韦伦Efavirenz | Tier B · 提前布局 | - |
| 氯马昔巴特Maralixibat Chloride | Tier C · 观察 / 贸易 | - |
| 氢溴酸依他佐辛Eptazocine hydrobromide | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
N-(4-chlorophenyl)pivalamide→1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone→ethynylcyclopropane→1-(chloromethyl)-4-methoxybenzene→1-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-2,2,2-trifluoroethanone→(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol→(S)-2-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→(S)-6-chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
N-(4-chlorophenyl)pivalamide→1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone→ethynylcyclopropane→1-(chloromethyl)-4-methoxybenzene→1-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-2,2,2-trifluoroethanone→(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol→(S)-2-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→(S)-6-chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
diethyl 2,2-dibutylmalonate→2,2-dibutylpropane-1,3-diol→1,3,2-Dioxathiane, 5,5-dibutyl-, 2-oxide→1,3,2-Dioxathiane, 5,5-dibutyl-, 2,2-dioxide→4-fluoro-2-(4-methoxybenzyl)benzenethiol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylthio)methyl)hexan-1-ol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylsulfinyl)methyl)hexan-1-ol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylsulfinyl)methyl)hexanal→1-Benzothiepin-4-ol, 3,3-dibutyl-7-fluoro-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1-oxide, (4R,5R)→1-Benzothiepin-4-ol, 3,3-dibutyl-7-fluoro-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)→1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)-rel→1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-hydroxyphenyl)-, 1,1-dioxide, (4R,5R)→1,4-bis(chloromethyl)benzene→1-Benzothiepin-4-ol, 3,3-dibutyl-5-[4-[[4-(chloromethyl)phenyl]methoxy]phenyl]-7-(dimethylamino)-2,3,4,5-tetrahydro-, 1,1-dioxide, (4R,5R)→4-fluorophenol→1-(chloromethyl)-4-methoxybenzene→4-fluoro-2-(4-methoxybenzyl)phenol→dimethylcarbamothioic chloride→O-4-fluoro-2-(4-methoxybenzyl)phenyl dimethylcarbamothioate
1,4-Dioxaspiro[4.5]decan-8-one→Hydroxylamine hydrochloride→N-{1,4-dioxaspiro[4.5]decan-8-ylidene}hydroxylamine→N-[(Methanesulfonyl)oxy]-1,4-dioxaspiro[4.5]decan-8-imine→10-[(4-Methoxyphenyl)methyl]-8-methyl-1,4-dioxa-8-azaspiro[4.6]undecan-9-one→1,4-Dioxa-8-azaspiro[4.6]undecan-9-one→Iodomethane→8-Methyl-1,4-dioxa-8-azaspiro[4.6]undecan-9-one→4-Methoxybenzyl chloride→4-Nitrobenzoic acid 10-[(4-methoxyphenyl)methyl]-8-methyl-1,4-dioxa-8-azaspiro[4.6]undecane→6-[(4-Methoxyphenyl)methyl]-1-methylazepan-4-one→6-[(4-Methoxyphenyl)methyl]-1,4-dimethylazepan-4-ol
本站可供应的对应中间体
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