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CAS 87-69-4
(2R,3R)-2,3-dihydroxysuccinic acid
登记编号：ESKE-002、VINF-002、EPTI-054、NELF-028
应用背景（按来源药适应症）
重度抑郁症盐酸艾司氯胺酮自杀意念盐酸艾司氯胺酮抑郁症盐酸艾司氯胺酮麻醉盐酸艾司氯胺酮难治性抑郁症盐酸艾司氯胺酮疼痛盐酸艾司氯胺酮泌尿系肿瘤酒石酸长春氟宁尿路上皮癌酒石酸长春氟宁乳腺癌酒石酸长春氟宁肺癌酒石酸长春氟宁胃癌酒石酸长春氟宁阴茎癌酒石酸长春氟宁不稳定型心绞痛依替巴肽心肌梗塞依替巴肽缺血性卒中依替巴肽急性冠脉综合征依替巴肽镰状细胞血症依替巴肽ST段抬高型心肌梗死依替巴肽HIV感染甲磺酸奈非那韦骨髓纤维化甲磺酸奈非那韦子宫颈功能不全甲磺酸奈非那韦系统性红斑狼疮甲磺酸奈非那韦非小细胞肺癌甲磺酸奈非那韦巨细胞病毒性视网膜炎甲磺酸奈非那韦
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-L-cysteine→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid→3-(tritylthio)propanoic acid→(S)-pyrrolidine-2-carboxylic acid→(S)-tert-butyl 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(((S)-1-((S)-2-(((R)-1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-4-oxobutanoate→L-cysteine hydrochloride→(R)-(9H-fluoren-9-yl)methyl (1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamate→(2R,3R)-2,3-dihydroxysuccinic acid→(R)-2-amino-3-(tritylthio)propanamide (2R,3R)-2,3-dihydroxysuccinate→(R)-1-((S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanamido)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylic acid→EPTI-057→EPTI-058→(S)-2-amino-3-(1H-indol-3-yl)propanoic acid→(S)-2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoic acid→3-bromoprop-1-ene→(R)-2-allyl 1-tert-butyl pyrrolidine-1,2-dicarboxylate→(R)-allyl 1-((S)-2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→(R)-allyl 1-((S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanamido)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→EPTI-065→EPTI-066→EPTI-067
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→(3S,4aS,8aS)-N-(tert-butyl)-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)decahydroisoquinoline-3-carboxamide→(2R,3R)-2,3-dihydroxysuccinic acid→(4S,5S)-dimethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate→((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)dimethanol→((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→(2S,3S)-2,3-dihydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate)→((4R,5R)-2-oxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→((4R,5R)-2,2-dioxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→sodium (2S,3S)-3-azido-1,4-bis(tosyloxy)butan-2-yl sulfate→(2S,3S)-2-azido-3-hydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate)→(2S,3S)-3-hydroxy-1,4-bis(tosyloxy)butan-2-aminium chloride→3-(chlorocarbonyl)-2-methylphenyl acetate→3-((S)-4-((S)-1-hydroxy-2-(tosyloxy)ethyl)-4,5-dihydrooxazol-2-yl)-2-methylphenyl acetate
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